MEDICAL AND SOCIAL SIGNIFICANCE OF OSTEOPOROSIS AND ITS COMPLICATIONS AGAINST THE BACKGROUND OF CORONAVIRUS INFECTION
DOI:
https://doi.org/10.32782/pub.health.2024.2.4Keywords:
osteoporosis, women, hypocalcemia, vitamin D deficiency, COVID-19Abstract
Topicality. The global pandemic significantly affects the health of patients with chronic non-communicable diseases, which include osteoporosis, therefore, to establish the mechanisms of development of bone pathologies associated with COVID-19, further detailed studies with simultaneous long-term observation of patients who were infected with SARSCoV- 2. The purpose of the work is to determine changes in mineral metabolism indicators associated with COVID-19 and assess their impact on bone mass reduction and the risk of developing osteoporosis. Materials and methods. The main clinical and laboratory indicators and the level of mineral status in the blood of patients with coronavirus infection on the first day of hospitalization. Research results. It was shown that the vast majority of patients (24 out of 30; 80%) had vitamin D deficiency upon admission to the hospital, which was evidenced by a low (<20 ng/ml) 25(OH) D level. Also, according to the rank correlation analysis data, a statistical tendency to an inverse relationship between the concentration of serum potassium and phosphorus and markers of inflammation, in particular, ferritin and C-reactive protein, was revealed. Conclusions. Timely detection of hypocalcemia and vitamin D deficiency with subsequent drug correction will contribute to the further prevention of pathological bone loss caused by SARS-CoV-2 infection, which will reduce the manifestations of osteoporosis.
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