SANITARY, HYGIENE, ETHICAL AND MEDICO-LEGAL PRINCIPLES OF SUCCESSFUL ORGANIZATION OF EXPERIMENTAL WORK ON ANIMALS

Abstract

Topicality. In modern conditions, neither medicine, nor pharmaceutics, nor biology can do without experimental research on animals. Since such studies are of a large-scale nature, many sanitary-hygienic, organizational and medico-legal issues arise regarding the performance of such experimental works. The purpose of the work is to determine the optimal approaches to conducting experimental work on animals based on the analysis of known literary sources, normative acts, regulations, relevant orders regarding the basic sanitaryhygienic, deontological and medico-legal principles, which would provide an opportunity to obtain an adequate and maximally correct result. Materials and methods. The article deals with the definition of the basic sanitary-hygienic, deontological and medicolegal principles that should be applied in the preparation and conduct of experimental work on animals based on the analysis of known literary sources, normative acts, provisions and relevant experience of working in the conditions of the vivarium of the National Pirogov Memorial Medical University (Vinnytsya, Ukraine). Research results. Based on the presented material, the authors conclude on the adequacy and necessity of conducting experimental scientific research on animals, which should include the following actions. The experiment should be conducted in vivarium conditions; the study is approved by the bioethics committee; the rule of three R (Replacement, Reduction, Refinement) is used; animals must have adequate food, water and care; surgical manipulations are performed only after anesthesia; the withdrawal of animals from the experiment should be carried out in extreme cases and under anesthesia. Conclusions. 1. Adherence to appropriate sanitary, hygienic and humane approaches when working in a vivarium, make it possible to conduct adequate experimental studies causing minimal harm to animals. 2. The obtained results of such scientific research can approach ideal only when the above basic principles are observed. The sequence of such principles should be used for conducting scientific work based on relevant international and Ukrainian documents on conducting scientific experiments, biological testing and the educational process using animals.