MODIFIED RISK ASSESSMENT OF ELECTRONIC NICOTINE DELIVERY SYSTEMS AS A COMPONENT OF PRIMARY PREVENTION OF DISEASES OF THE CIRCULATORY SYSTEM
DOI:
https://doi.org/10.32782/pub.health.2025.2.6Keywords:
electronic nicotine delivery systems, circulatory system diseases, harmful and potentially harmful substances, primary preventionAbstract
Topicality. Smoking is a recognized risk factor for circulatory system diseases, as it causes chronic inflammatory process, pro-oxidant stress, which affects the functions of the vascular wall, accelerating the manifestations of atherosclerosis. Given the harmful effects of smoking, electronic nicotine delivery systems have recently become widespread, the frequency and impact of which leaves a significant list of uncertain debatable issues. The purpose of the work is to determine whether the use of electronic nicotine delivery systems poses a lower risk to health and the development of circulatory system diseases than the continuation of classic smoking. Materials and methods. The study used information search, analytical materialsfrom literary sources, WHO scientific reports, regulatory documents, PubMed and MEDLINE databases. The results were summarized regarding the assessment of the modified risk of electronic nicotine delivery systems. Research results. It wasfound that most components of tobacco smoke are not toxicants, but about a hundred of them are recognized as harmful or potentially harmful substances. It was found that currently the Food and Drug Administration in the United States (FDA) has created guidance documents and rules that oblige tobacco manufacturers to report the amount of each harmful and potentially harmful substance measured in a tobacco product. Today, there are three lists of harmful and potentiallyharmful substances in the world, most of which focus on chemical compounds that affect the development of the fivemost serious consequences of smoking: cancer, circulatory system diseases, bronchopulmonary diseases, reproductive problems and nicotine addiction. In accordance with the specified requirements of guidance documents and rules, the impact of one of the most common modern nicotine delivery systems, IQOS, was assessed based on scientific publications.Conclusions. As a result of the analysis of scientific research, guidance documents and regulations, it was found that the aerosol of the most common modern nicotine delivery system IQOS has an average of 95% lower level of a numberof harmful and potentially harmful substances compared to the smoke from smoking classic cigarettes. This is due to the avoidance of the combustion process, reduced contact with harmful and potentially harmful substances, as well as newapproaches to assessing the modified risk of smoking on the development of circulatory system diseases and others.
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