FEATURES OF THE USE OF ULTRASOUND EXAMINATION IN THE DIAGNOSIS OF COMMUNITY-ACQUIRED PNEUMONIA BEFORE AND DURING THE COVID-19 PANDEMIC

Authors

DOI:

https://doi.org/10.32782/pub.health.2023.3.4

Keywords:

Lung ultrasound (LUS), community-acquired pneumonia (CAP), COVID-19

Abstract

Relevance. Early and accurate diagnosis of community-acquired pneumonia (CAP) is crucial for effective treatment and prevention of complications. The traditional method of diagnosing CAP is chest radiography (CXR). However, chest X-rays have limitations such as low sensitivity in detecting small or peripheral infiltrates and exposure to ionising radiation. In contrast, lung ultrasound can detect small and peripheral lung lesions with higher sensitivity than CXR and is a quick and safe method. The purpose of this study is to determine the value, reliability and importance of lung ultrasound for the diagnosis of CAP. Materials and methods. The method of ultrasonography, systematic and analytical method of analysis (for the study of scientific, methodological and analytical documents, namely: articles, research and meta-analyses), as well as statistical, descriptive, graphical methods and the method of mathematical analysis, were used. Results. The sensitivity of ultrasound in the diagnosis of community-acquired pneumonia (before the COVID-19 pandemic) ranged from 83% to 95%, which is a very good indicator. Average sensitivity of ultrasound for the diagnosis of pneumonia: 90.67%. The average specificity of ultrasound for the diagnosis of CAP is 91.33%. Pooled data from meta-analyses during the COVID-19 pandemic showed that ultrasound has a high sensitivity of 90% and a moderately low specificity of 70.6% for the diagnosis of COVID-19 pneumonia compared to CT chest. Thus, ultrasound has a high sensitivity for true positives (90%) and a low false-negative rate compared to CT. When performing ultrasound examinations during an outpatient visit, we found that 55.4% of patients had pleuropulmonary changes, including 32% of patients with ultrasound signs of viral pneumonia with varying degrees of severity. No pathology was detected in 41.2% of patients. Conclusions. Ultrasound examination provides a good result in achieving diagnostic, prognostic and therapeutic goals. Ultrasound is an excellent tool at the point of care and can help in early diagnosis, therapeutic decision-making and follow-up monitoring of pneumonia, especially in intensive care and in pregnant women, children and patients in areas with high rates of infection transmission. Ultrasonography of the lungs can reduce the use of radiological diagnostic imaging. Ultrasonography can determine the extent of lung involvement in CAP (including SARS-CoV-2-associated CAP) and allow for timely treatment.

References

Reissig, A.; Copetti, R. Lung ultrasound in community-acquired pneumonia and in interstitial lung diseases. Respiration 2014, 87, 179–189. URL: https://pubmed.ncbi.nlm.nih.gov/24481027/.

Targhetta R, Chavagneux R, Bourgeois JM, Dauzat M, Balmes P, Pourcelot L.J («Sonographic approach to diagnosing pulmonary consolidation» Ultrasound Med.) 1992.

Gehmacher O., Mathis G., Kopf A., Scheier M. («Ultrasound imaging of pneumonia». Ultrasound Med Biol.), 1995.

D Lichtenstein, G Mézière, P Biderman, A Gepner, O Barré «The comet-tail artifact. An ultrasound sign of alveolarinterstitial syndrome». Pubmed, 1997.

Dietrich C.F., Hirche T.O., Schreiber D.G., Wagner T.O.F. «Ultrasonography of pleura and lung». Ultraschall Med., 2003.

Lichtenstein D.A., Lascols N., Meziere G., Gepner A. («Ultrasound diagnosis of alveolar consolidation in the critically ill». Intensive Care Med., 2004.

Targhetta R, Chavagneux R, Balmes P, Lemerre C, Mauboussin JM, Bourgeois JM, Pourcelot L.J Sonographic lung surface evaluation in pulmonary sarcoidosis: preliminary results. Ultrasound Med. 1994 May; 13 (5):381-8. doi: 10.7863/jum.1994.13.5.381.

Lichtenstein DA, Meziere G, Biderman P, Gepner A, Barre O: The comet-tail artifact. An ultrasound sign of alveolarinterstitial syndrome. Am J Respir Crit Care Med. 1997, 156: 1640–1646.

Daniel Lichtenstein, M.D.; Ivan Goldstein, M.D.; Eric Mourgeon, M.D.; Philippe Cluzel, M.D., Ph.D.; Philippe Grenier, M.D.; Jean-Jacques Rouby, M.D., Ph.D. Comparative Diagnostic Performances of Auscultation, Chest Radiography, and Lung Ultrasonography in Acute Respiratory Distress Syndrome. URL: https://doi.org/10.1097/00000542-200401000-00006.

Giovanni Volpicelli, Mahmoud Elbarbary, Michael Blaivas, at all International evidence-based recommendations for point-of-care lung ultrasound. International Liaison Committee on Lung Ultrasound (ILC-LUS) for the International Consensus Conference on Lung Ultrasound (ICC-LUS). Intensive Care Medicine volume 38, pages577–591 (2012)/Published: 06 March 2012. URL: https://link.springer.com/article/10.1007/s00134-012-2513-4.

Miles MJ, Islam S. Point of care ultrasound in thoracic malignancy. Ann Transl Med. (2019) 7:350. doi: 10.21037/atm.2019.05.53. URL: https://atm.amegroups.com/article/view/26202/24898.

Sperandeo M, Filabozzi P, Varriale A, Carnevale V, Piattelli ML, Sperandeo G, et al. Role of thoracic ultrasound in the assessment of pleural and pulmonary diseases. J Ultrasound. (2008) 11:39–46. doi: 10.1016/j.jus.2008.02.001. URL: https://pubmed.ncbi.nlm.nih.gov/23396553/.

Roy A. An application of linear mixed effects model to assess the agreement between two methods with replicated observations. J Biopharm Stat. (2009) 19:150–73. doi: 10.1080/10543400802535141. URL: https://pubmed.ncbi.nlm.nih.gov/19127473/.

Sperandeo M, Trovato FM, Dimitri L, Catalano D, Simeone A, Martines GF, et al. Lung transthoracic ultrasound elastography imaging and guided biopsies of subpleural cancer: a preliminary report. Acta Radiol. (2015) 56:798–805. doi: 10.1177/0284185114538424. URL: https://pubmed.ncbi.nlm.nih.gov/24951615/.

Staub LJ, Mazzali Biscaro RR, Kaszubowski E, et al. Lung ultrasound for the emergency diagnosis of pneumonia, acute heart failure, and exacerbations of chronic obstructive pulmonary disease/asthma in adults: a systematic review and meta-analysis. J Emerg Med. 2019;56:53–69. URL: https://pubmed.ncbi.nlm.nih.gov/30314929/.

Marin JR, Abo AM, Arroyo AC, et al. Pediatric emergency medicine point-of-care ultrasound: summary of the evidence. Crit Ultrasound J. 2016;8:16. URL: https://pubmed.ncbi.nlm.nih.gov/27812885/.

Frankel HL, Kirkpatrick AW, Elbarbary M, et al. Guidelines for the appropriate use of bedside general and cardiac ultrasonography in the evaluation of critically ill patients-part I: general ultrasonography. Crit Care Med. 2015;43:2479–502. URL: https://pubmed.ncbi.nlm.nih.gov/26468699/.

Soni NJ, Schnobrich D, Mathews BK, et al. Point-of-care ultrasound for hospitalists: a position statement of the Society of Hospital Medicine. J Hosp Med. 2019;14:E1–6. URL: https://pubmed.ncbi.nlm.nih.gov/31561287/.

Staub LJ, Biscaro RRM, Kaszubowski E, et al. Chest ultrasonography for the emergency diagnosis of traumatic pneumothorax and haemothorax: a systematic review and meta-analysis. Injury. 2018;49:457–66. URL: https://pubmed.ncbi.nlm.nih.gov/29433802/.

Daniele De Luca, et al. International evidence-based guidelines on Point of Care Ultrasound (POCUS) for critically ill neonates and children issued by the POCUS Working Group of the European Society of Paediatric and Neonatal Intensive Care (ESPNIC). Source: Critical Care, 2020, 24:65 URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041196/.

New International Guidelines and Consensus on the Use of Lung Ultrasound Libertario Demi PhD, Frank Wolfram PhD, Catherine Klersy PhD, Annalisa De Silvestri PhD, Virginia Valeria Ferretti PhD, Marie Muller PhD, Douglas Miller PhD … See all authors First published: 22 August 2022. URL: https://doi.org/10.1002/jum.16088/.

Soldati G, Smargiassi A, Inchingolo R, et al. Proposal for international standardization of the use of lung ultrasound for patients with COVID-19: a simple, quantitative, reproducible method. J Ultrasound Med. 2020;39:1413–9. URL: https://pubmed.ncbi.nlm.nih.gov/32227492/.

Volpicelli G, Lamorte A, Villén T. What’s new in lung ultrasound during the COVID-19 pandemic. Intensive Care Med. 2020;46:1445–8. URL: https://pubmed.ncbi.nlm.nih.gov/32367169/.

URL: https://empendium.com/ua/chapter/B27.II.3.11.1.

Chavez, M. A., et al. Lung ultrasound for the diagnosis of pneumonia in adults: a systematic review and metaanalysis. Respiratory Research. 15, 50 (2014) 2014 Apr 23;15(1):50. doi: 10.1186/1465-9921-15-50.

Ling Long 1, Hao-Tian Zhao, Zhi-Yang Zhang, Guang-Ying Wang, He-Ling Zhao, Lung ultrasound for the diagnosis of pneumonia in adults: A meta-analysis, Medicine (Baltimore) 2017 Jan; 96(3):e5713. DOI: 10.1097/MD.0000000000005713.

Balk DS, Lee C, Schafer J, Welwarth J, Hardin J, Novack V, Yarza S, Hoffmann B. Lung ultrasound compared to chest X-ray for diagnosis of pediatric pneumonia: A meta-analysis. Pediatr Pulmonol. 2018 Aug;53(8):1130-1139. doi: 10.1002/ppul.24020. PMID: 29696826.

Yan JH, Yu N, Wang YH, Gao YB, Pan L. Lung ultrasound vs chest radiography in the diagnosis of children pneumonia: Systematic evidence. Medicine (Baltimore). 2020 Dec 11;99(50):e23671. doi: 10.1097/MD.0000000000023671. PMID: 33327356; PMCID: PMC7738074.

Xueyan Yuan 1, Ling Liu 1, Wei Chang 1, Zongsheng Wu 1, Lili Huang 1, Yali Chao 1, Xinxing Lu 1, Jianfeng Xie 1, Yi Yang 1, Haibo Qiu 1. DOI: 10.3389/fmed.2021.705960.

Lu X, Jin Y, Li Y, Weng L, Li H Diagnostic accuracy of lung ultrasonography in childhood pneumonia: a metaanalysis. Eur J Emerg Med. 2022 Apr 1;29(2):105-117. doi: 10.1097/MEJ.0000000000000883.

Дзюблик Я. О., 2020, Негоспітальна пневмонія і COVID-19: дискусійні питання. Національний інститут фтизіатрії і пульмонології ім. Ф. Г. Яновського НАМН України, www.search.crossref.org doi: 10.31215/2306-4927-2020-110-4-12-14. URL: http://www.ifp.kiev.ua/doc/journals/upj/20/pdf20-4/upj_2020_4_cont.htm.

Mengshu Wang, Xufei Luo, Ling Wang, Janne Estill, Meng Lv, Ying Zhu, Qi Wang, Xiaojuan Xiao, Yang Song, Myeong Soo Lee, Hyeong Sik Ahn, Junqiang Lei and Jinhui Tian «A Comparison of Lung Ultrasound and Computed Tomography in the Diagnosis of Patients with COVID-19: A Systematic Review and Meta-Analysis», 2021 Jul 27;11(8):1351. doi: 10.3390/diagnostics11081351.

Ashley K. Matthies et al. (2021) wrote a preprint article titled Diagnostic accuracy of point-of-care lung ultrasound for COVID-19: A systematic review and meta-analysis. Extension://elhekieabhbkpmcefcoobjddigjcaadp/https://www.medrxiv.org/content/10.1101/2021.10.09.21264799v1.full.pdf.

Reem Jari, Abdulrahman M Alfuraih, James R McLaughlan The diagnostic performance of lung ultrasound for detecting COVID-19 in emergency departments: A systematic review and meta-analysis. J Clin Ultrasound . 2022 Jun;50(5):618-627. doi: 10.1002/jcu.23184. Epub 2022 Mar 9. DOI: 10.1002/jcu.23184.

Giovanni Volpicelli, Mahmoud Elbarbary, Michael Blaivas, at all International evidence-based recommendations for point-of-care lung ultrasound. International Liaison Committee on Lung Ultrasound (ILC-LUS) for the International Consensus Conference on Lung Ultrasound (ICC-LUS). Intensive Care Medicine volume 38, pages577–591 (2012)/Published: 06 March 2012. https://link.springer.com/article/10.1007/s00134-012-2513-4.

Sezgin C, Gunalp M, Genc S, et al. Diagnostic value of bedside lung ultrasonography in pneumonia. Ultrasound Med Biol. 2020;46:1189–96. https://pubmed.ncbi.nlm.nih.gov/32063393/.

Published

2023-08-25

Issue

Section

Статті